http://www.fda.gov/OHRMS/DOCKETS/AC/prozac/2443T1.PDF

CASEY: Thank you. Debra Douglas?

DOUGLAS : Debra Douglas. Back in 1988 I sought

help for a reactive depression after the sexual assault on my

three-year-old son and subsequent court proceedings.

Prozac, new on the market, seemed a perfect drug for

me, or so said my doctor, because of the minimal side effects

namely, weight loss. I began taking 20 mg of Prozac and soon

found myself feeling very much back to my old self, energetic

and feeling good, but slowly felt as if it were wearing off

and I was gaining weight.

I questioned the doctor each time I went for my

prescription renewal how this could be; my eating habits

hadn’t changed. I was originally told I could expect a weigh

loss . In trying to obtain the desired effects, my doctor

increasing the dosage, with little apparent concern for

adverse effects.

By the end of a year and a half on Prozac my doctor had me at a

dosage rate of 80 mg. I questioned that other problems I was

having surely were related to Prozac, only to be told that there

no relation.

My gynecologist had referred me to the University of

Miami with my chart, across which was written "I give up." I

had lower abdominal pain accompanied by a spotty brown

discharge from my uterus that led to chronic bacterial

infections. I underwent diagnostic surgery, laparoscopy, and

D&C under general anesthesia. It was later suggested I have

a hysterectomy.

Trusting the doctors and their knowledge, I accepted

their answers that Prozac could not be related. At 80 mg I

was having the desired effects, according to my doctor. My

life was very much in order, things were going very well,

except for the continuing saga of the gyn problem.

I had finished my work day at the port for the

cruise line which I have worked for, for almost four years

now, and love working for, met my family at the ballfield for

my son’s baseball game. The game was fun, as usual, and when

it ended I left in my car. About two blocks from home I had

a seizure-like attack that came on suddenly. I somehow

reached home, collapsed in the door, and once my husband

reached home I was rushed by ambulance to the hospital.

I was having what they called an explosive headache

episode and was in extreme pain totally out of control. Many

tests were taken, The next day after

no real findings, I was released. After my release another

explosive headache episode occurred, with the same intensity, out

of the blue, as the first one. I was again rushed to emergency,

more tests, and a longer hospital stay. Again, no real findings
other than the suggestion by the neurologist that these headache

episodes were emotion-related.

After nine days of being on I.V. Demerol every

to six hours and suffering another attack while there, I

was released, sent home this time with a stronger barbiturate for

pain. I could not function normally. I tried going back to

work but the constant head pain that the pills didn’t relieve

was overwhelming. I became a desperate person.

One pain pill after another didn’t work, so I took

a handful one night. I woke up the next morning very sick.

My head hurt so badly I could barely hold it up. My husband,

sympathetic as he was, and not knowing I had taken an overdose

the night before, felt very helpless and left me to sleep that

morning after he’d seen the boys off to school. He kissed me

goodbye and said he’d be back in an hour, he had to run to the

bank.

For me to take the next step, a sudden impulsive

action that overrode all rational thoughts, needing to get up,

reach into the gun cabinet on the closet shelf, and make this

headache go away. I had to get the gun. I took the 9-mm

automatic, sat down on the bed, and put the gun to my head.

I wasn’t clear on how to shoot the gun, so I lowered it and

pulled the trigger. It fired into the bed. As I went to bolt

it back up to my head, the feather-touch trigger had tripped

after that first shot and I blew a four-inch hole out of the

bottom of my arm instead of my head.

That gun, I later learned, was loaded with hollowpoint

bullets, and I shudder to think what could have

happened. I also know how lucky I am to be here today. After

arm surgery and a one-week hospitalization, I spent another

three-and-a-half weeks in a private psychiatric hospital

recuperating.

After I was released, I began seeing how Prozac could have caused

this. I started putting this together well. No longer was I

bothered by the lower abdominal pain. I was free of infection. I

hadn’t had a headache in several weeks, and I had also been off

the Prozac for a month then.

My gynecologist sees no reason for doing

hysterectomy, as my gyn checkup is completely normal. To this

date I’ve not had a recurrence of the gyn problem and I’ve not

had one headache episode or head pain that I feel certain

Prozac caused. Prozac did this to me. Had someone looked

further into Prozac, believe me, even mentioned early on of

the so-called remote possibility that Prozac could cause any

of these adverse effects, especially the act of putting a

loaded gun to my head, to want to die so violently, steps

could have been taken to avoid it. Thank God I was a lousy

shot .

As you hear the many stories today, you can see we

are real people, not small percentage numbers of a minority

suffering these silenced adverse effects. Please look at us,

listen to us, take this Prozac off the market until it can be

proven 100-percent free against violent turns in personality,

until Eli Lilly can give assurance that the psychiatrists and

general practitioners that are so quick to hand out this

prescription are aware of all side effects, and information I

passed down to all patients. Thank you.