Mania & Psychosis Antidepressants 2004-02-02 U.S.A. ++200,000 a Year Enter Hospital Due to Antidepressant- Induced Mania/ Psychosis: FDA Testimony

Journal Article reference is from the Journal of Clinical Psychiatry 2001: 62: 30-33 titled: Antidepressant-Associated Mania and Psychosis Resulting in Psychiatric Admissions  by Adrian Preda, M.D.; Rebecca W. MacLean, M.D.; Carolyn M. Mazure, Ph.D.; and Malcolm B. Bowers, Jr., M.D.

DR. RUDORFER:  Thank you. We are up to speaker 20.

                       Rosie Carr Meysenburg

             MS. MEYSENBURG:  My name is Rosie Carr

   Meysenburg. I am from Dallas, Texas.  I have no

   financial ties with anybody but my husband of 40


             In my handout, I have highlighted what I

   am speaking about here.

             The first paper is a personal letter from

   Dr. Peter S. Jensen.  At that time, he was the head

   of Child & Adolescent Disorders Research Branch of

   the NIMH, the National Institute of Mental Health.

   He said that research indicates that

   antidepressants for depressed adolescents are not

   very effective.

             The second paper is a personal letter from

   Dr. Larry S. Goldman, Director of the AMA, the

   American Medical Association.  He writes physicians

   have known for many years the dangers of giving any

   antidepressant to patients with certain disorders.

   There is a substantial risk of precipitating mania

   or psychosis.

             The last item is a journal article from

   the Journal of Clinical Psychiatry researched at

   Yale University.  It states that 11 percent of all
   psychiatric hospital admissions were from

   antidepressant-induced mania and psychosis.

             It also states another area of research

   that would be relevant to this issue is the work of

   Winter and colleagues showing that Prozac and other

   SSRIs can simulate the effects of LSD.  In other

   words, this is saying for some people, taking an

   SSRI is the same as taking LSD.

             About two million people enter a

   psychiatric hospital every year, 11 percent then is

   over 200,000 people a year who have an

   antidepressant-induced psychosis and who are

   hospitalized.  Not all are hospitalized.  Some of

   them have either committed suicide, a homicide, or

   a murder/suicide.