Withdrawal can often be more dangerous than continuing on
a medication. It is important to withdraw extremely slowly from
these drugs, usually over a period of a year or more, under the
supervision of a qualified specialist. Withdrawal is sometimes
more severe than the original
symptoms or problems.
This web site focuses on the Selective
Serotonin Reuptake Inhibitors (SSRIs), of which Prozac
(fluoxetine) was the first. Other SSRIs are Zoloft
(sertraline), Paxil (paroxetine) (known in the UK as Seroxat), Celexa (citalopam), Lexapro
(escitalopram), and Luvox (fluvoxamine). Other newer antidepressants included in this list are Remeron
(mirtazapine), Anafranil (clomipramine) and the SNRIs Effexor (venlafaxine), Cymbalta
and Pristiq (desvenlafaxine) as well as the dopamine
reuptake inhibitor antidepressant Wellbutrin (bupropion) (also marketed as Zyban).
As Dr. David Healy notes in his article "Welcome to Data Based Medicine",
'Third: This site will in due course have a category of posts for people who
have been through the system, people who have had partners, parents, children or
friends injured by treatments and who have found themselves trapped in a
Kafkaesque world when they have sought help from doctors, regulators or others
who seem to be there to help us. These stories are aimed at highlighting the
lunacy of the current system but also showing how someone who is determined can
change everything. These stories will likely migrate to:
when it is up and running.' Sign up now and be prepared to tell your
On December 15, 2010, PLoS Medicine released
a study which showed that, in regard to prescription medications and violence, the FDA
had received the most reports of violence from the SSRI & SNRI antidepressants
(except for Chantix, the smoking cessation drug.)
The study listed Prozac as the
number 2 drug for violence, and Paxil as number 3.
This massive index of over 4,800 cases [which contains over 100
categories] is now capable of showing singly the 13 most important
categories by clicking on the following links:
Antidepressants have been recognized as potential
inducers of mania and psychosis since their introduction in the 1950s. Klein
and Fink1 described psychosis as an adverse effect of the older
tricyclic antidepressant imipramine. Since the introduction of Prozac in
December, 1987, there has been a massive increase in the number of people taking
antidepressants. Preda and Bowers2 reported that over 200,000 people
a year in the U.S. enter a hospital with antidepressant-associated mania and/or psychosis.
The subsequent harm from this prescribing can be seen in these 4,800+ stories.
Before the introduction of Prozac in Dec.
1987, less than one percent of the population in the U.S. was diagnosed
with bipolar disorder – also known as manic depression. Now, with
the widespread prescribing of antidepressants, the percent of the population in
the United States that is diagnosed with bipolar disorder (swing from depression
to mania or vice versa) has risen to 4.4%3
. This is almost one out of every 23
people in the U.S.
The Physicians' Desk Reference
The Physicians' Desk Reference lists the following adverse reactions
(side effects) to antidepressants among a host of other physical and
neuropsychiatric effects. None of these adverse reactions (side effects)
is listed as Rare. They are all listed as either Frequent or as
Hypomania (e.g., poor
judgment, over spending, impulsivity, etc.)
Emotional Lability (Or Instability)
Alcohol Abuse and/or Craving
Akathisia (Severe Inner Restlessness)
Discontinuation (Withdrawal) Syndrome
Adverse reactions are most likely to occur when
starting or discontinuing the drug, increasing or lowering the dose or when switching
from one SSRI to another. Adverse reactions are often diagnosed as
bipolar disorder when the symptoms may be entirely iatrogenic (treatment
induced). Withdrawal, especially abrupt withdrawal, from
any of these medications can cause severe neuropsychiatric and physical
symptoms. It is important to withdraw extremely slowly from these drugs, often
over a period of a year or more, under the supervision of a qualified and
experienced specialist, if available.
sometimes more severe than the original symptoms or problems.
66 School Shootings/Incidents Involving SSRIs
Most of the stories on this site describe events that occurred after the year
2000. The increase in
online news material and the efficiency of search engines has greatly increased the ability to track stories. Even
these 4,800+ documented stories only represent the tip of an iceberg since most
stories do not make it into the media. There are
115 cases of bizarre behavior,
66 school shootings/incidents,
68 road rage tragedies,
19 air rage incidents, 101 arson cases, 70 postpartum depression cases, over 1,000 murders (homicides)
or murder attempts, over 300
murder-suicides (30% committed by women)
and other acts of violence including workplace violence on this site.
There are also over 100 Journal Articles and FDA reports
listed in the Index. They are at the top of the Index immediately below
the 66 school shootings/incidents and the 29 "won" criminal cases.
FDA Public Health Advisory
On March 22, 2004 the FDA published a Public Health Advisory
that reiterates several of these side effects and states (in part) "Anxiety, agitation, panic attacks, insomnia,
irritability, hostility, impulsivity, akathisia (severe restlessness),
hypomania, and mania have been reported in adult and pediatric patients being
treated with antidepressants for major depressive disorder as well as for other
indications, both psychiatric and non-psychiatric." (Click Links
button at bottom of this page for a direct link to this FDA Warning.)
On September 14, 2004 the FDA added a Black Box Warning in regard to
antidepressants & suicidality in those under age 18.
On September 14, 2004 the FDA
mandated that pharmacies provide to all parents or guardians for
those younger than 18 an Antidepressant Patient Medication Guide.
This guide reads (in part) "Call healthcare provider right away if you or
your family member has any of the following symptoms: Acting aggressive,
being angry, or violent & acting on dangerous impulses." This
Antidepressant Patient Medication Guide also states "Never stop an
antidepressant medicine without first talking to a healthcare provider. Stopping an antidepressant medicine suddenly can cause other symptoms."
(Click Links button at bottom of this page for a direct link to this
FDA Antidepressant Guide.)
13, 2006, the Black Box
Warning for suicidality was updated to include those under age 25. The Black Box Warning is included in the insert to the drugs and in the Physicians' Desk reference.
An Absence of Controlled Scientific Evidence
In the Journal of American Physicians and
Surgeons, Volume 14, Number 1, Spring 2009, there is a journal article by
Joel M. Kauffman, Ph.D., which is titled: Selective Serotonin Reuptake
Inhibitor (SSRI) Drugs: More Risk Than Benefits?" In reference to
SSRIStories.com, Dr. Kaufmann made the following statement: "Since no
clinical trial involving multiple homicides is ever likely to be run, no firmer
evidence is likely to be found. Healy noted that much of the evidence for
suicide and murder came from the efforts of journalists and lawyers".
To read the full article go to the Links page on this site (click the button at
the bottom of this page).
Japanese Warning on Violence
The Ministry of Health, Labor and Welfare
in Japan has investigated reports where people on antidepressants have committed
sudden acts of violence against others. The agency has decided torevise
the warnings on the medication guide to read, "There are cases where we
cannot rule out a causal
relationship with the medication."
A Public Health Problem of Epidemic Proportions
There is a grave concern among advocates that adverse reactions are greatly
underestimated by the public, the medical profession, and the regulatory
authorities. Each of these stories in our list can be interpreted as an adverse
reaction and in most cases we have highlighted the portion of the article that
refers to evidence of bizarre behavioral change consistent with drug reaction.
In some stories causation is acknowledged and the juxtaposition of these stories
with those where it goes unrecognized as well as the repetition of themes and
circumstances is chilling. If indeed medications played a significant role in
all these tragedies, then this is a public health problem of epidemic
proportions on a global scale.
How to Use This Web Site
To enter the site, click on the button below. This will bring up the site index.
The index contains 5 columns, each with its own column header
displayed in red. Clicking on the
column header will re-sort the index according to that heading. A link to the
complete media article or testimony, often with a summary heading, is available
by clicking on the "What" column entry displayed in blue.
There are 2 flags set in the index which have special meaning as follows:
If the first character of the "Additional" column is a special character sequence (*,**,+,++), then the moderators of
SSRIStories consider that story to be of special interest.
** Indicates a school shooting or school incident.
Indicates a legal case won using SSRI
Indicates an important journal article.
Indicates a highly publicized case.
If the last character of the "Drug" column is an asterisk, it indicates some expert has indicated the drug contributed to the events documented in the story.
1 Klein DF, Fink M.
Psychiatric Reaction Patterns to Imipramine. Am Journal Psychiatry 1962; 119:
2 Preda and Bowers. Antidepressant-Associated Mania and
Psychosis Resulting in Psychiatric Admissions . Journal of Clinical
Psychiatry 2001: 62: 30-33
3National Institute of Mental
Health: Health Magazine 2010
J. Moore, Joseph Glenmullen, Curt D. Furberg.
Drugs Associated With Reports of Violence Toward Others. PLoS Medicine: December 15, 2010
You may use Google to search SSRI Stories
web site. Use the 'Back' button on your browser to get back here.
DISCLAIMER: This site is in no way associated with
either the Church of Scientology or the Citizens Commission on Human